TBC1D7 antibody (C-Term)

Catalog No. ABIN2786978

This Rabbit Polyclonal antibody specifically detects TBC1D7 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit and Pig.

Quick Overview for TBC1D7 antibody (C-Term) (ABIN2786978)

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBC1D7 Antibody

Binding Specificity: C-Term

Sequence: ISRCFVKQLN NKYRDALPQL PKAFEQYLNL EDSRLLSHLK TCSAVSKLPY

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Tbc1d7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Tbc1d7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 293 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TBC1D7

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Alternative Name: Tbc1d7

Background: Tbc1d7 is a component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Alias Symbols: 2610009C09Rik
Protein Interaction Partner: Ywhae,
Protein Size: 293

Molecular Weight: 32 kDa

Gene ID: 67046

NCBI Accession: NM_025935, NP_080211

UniProt: Q9D0K0