PNRC2 antibody (Middle Region)

Catalog No. ABIN2787028

This Rabbit Polyclonal antibody specifically detects PNRC2 in WB. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Guinea Pig, Horse, Cow, Dog and Zebrafish (Danio rerio).

Quick Overview for PNRC2 antibody (Middle Region) (ABIN2787028)

Target: PNRC2 (Proline Rich Nuclear Receptor Coactivator 2 (PNRC2))

Reactivity: Human, Rat, Mouse, Rabbit, Guinea Pig, Horse, Cow, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNRC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PNRC2 Antibody

Binding Specificity: Middle Region

Sequence: NQSWNSSLSG PRLLFKSQAN QNYAGAKFSE PPSPSVLPKP PSHWVPVSFN

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PNRC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PNRC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 139 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PNRC2

Target: PNRC2 (Proline Rich Nuclear Receptor Coactivator 2 (PNRC2))

Alternative Name: PNRC2

Background: PNRC2 is involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery.PNRC2 may act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. PNRC2 is required for UPF1/RENT1 localization to the P-body. PNRC2 also acts as a nuclear receptor coactivator. PNRC2 may play a role in controlling the energy balance between energy storage and energy expenditure.
Alias Symbols: FLJ20312, MGC99541
Protein Interaction Partner: DCP1A, ESRRG, UBC, SF1, GLOD4, SPAG9, ZBTB48, XRCC6, RORA, RARG, HNF4G, HNF4A, NR5A2, ESR2, ESR1, ZBTB16, RORB, ESRRA, RARA, AR, NR5A1,
Protein Size: 139

Molecular Weight: 15 kDa

Gene ID: 55629

NCBI Accession: NM_017761, NP_060231

UniProt: Q9NPJ4