MAPK7 antibody (Middle Region)

Catalog No. ABIN2787362

This anti-MAPK7 antibody is a Rabbit Polyclonal antibody detecting MAPK7 in WB and IHC. Suitable for Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig and Horse.

Quick Overview for MAPK7 antibody (Middle Region) (ABIN2787362)

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MAPK7 Antibody

Binding Specificity: Middle Region

Sequence: FDMGVADGPQ DGQADSASLS ASLLADWLEG HGMNPADIES LQREIQMDSP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MAPK7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MAPK7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 816 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Alternative Name: MAPK7

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Alias Symbols: BMK1, ERK4, ERK5, PRKM7
Protein Interaction Partner: PRKCZ, NFE2L2, UBE2C, MAP3K2, TP53, MAP2K5, PML, DSG1, DSC1, PFDN6, VBP1, MAPK7, PFDN5, PFDN4, PFDN2, PFDN1, JUP, GAPDH, BAG3, PKM, LDHC, HSP90AB1, HSPA5, HSPA4, ATP5A1, ACTB, PPP3CA, TUBB, MYLK2, GANAB, CDC37, YWHAZ, YWHAH, YWHAG, YWHAE, UBC, HSP90B1, FS
Protein Size: 816

Molecular Weight: 88 kDa

Gene ID: 5598

NCBI Accession: NM_139034, NP_620603

UniProt: Q13164

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling