KDM4B antibody (Middle Region)

Catalog No. ABIN2787663

Product Details anti-KDM4B Antibody

Target: KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))

Binding Specificity: Middle Region

Reactivity: Human, Horse, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM4B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CAICTLFYPY CQALQTEKEA PIASLGEGCP ATLPSKSRQK TRPLIPEMCF

Predicted Reactivity: Dog: 92%, Horse: 92%, Human: 100%, Pig: 92%

Characteristics: This is a rabbit polyclonal antibody against JMJD2B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human JMJD2B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1096 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KDM4B

Target: KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))

Alternative Name: JMJD2B (KDM4B Products)

Synonyms: KDM4B antibody, JMJD2B antibody, jmjd2b antibody, si:ch211-124a3.4 antibody, TDRD14B antibody, 4732474L06Rik antibody, Jmjd2b antibody, mKIAA0876 antibody, lysine demethylase 4B antibody, lysine (K)-specific demethylase 4B antibody, KDM4B antibody, kdm4b antibody, Kdm4b antibody

Background: JMJD2 family proteins are classified into one group with JD2H and TUDOR domains and another group without JD2H or TUDOR domains. Because JMJD2C gene (also known as GASC1 gene) is amplified in esophageal squamous cell carcinoma (ESCC), JMJD2 family genes are cancer-associated genes. Human genes corresponding to KIAA0677, KIAA0876, KIAA0780 and FLJ10251 cDNAs were designated JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. In addition, JMJD2D homologous genes within human genome sequences AP002383.3 and AP001264.4 were designated JMJD2E and JMJD2F, respectively. C2HC2HC2- and C5HC2-type Cys (His) clusters were identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins. JMJD2A, JMJD2B and JMJD2C consist of JmjN, JmjC, JD2H, and two TUDOR domains.
Alias Symbols: FLJ44906, KDM4B, KIAA0876, JMJD2B
Protein Interaction Partner: UBC, H3F3C, HSP90B1, HSP90AA2P, SMU1, KMT2C, WDR5, ASH2L, KMT2D, RBBP5, HSPA4, HNRNPU, ESR1, MED10,
Protein Size: 1096

Molecular Weight: 122 kDa

Gene ID: 23030

NCBI Accession: NM_015015, NP_055830

UniProt: O94953

Pathways: Warburg Effect