TMED10 antibody (Middle Region)

Catalog No. ABIN2787806

This anti-TMED10 antibody is a Rabbit Polyclonal antibody detecting TMED10 in WB. Suitable for Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Zebrafish (Danio rerio), Guinea Pig and Saccharomyces cerevisiae.

Quick Overview for TMED10 antibody (Middle Region) (ABIN2787806)

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Zebrafish (Danio rerio), Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMED10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TMED10 Antibody

Binding Specificity: Middle Region

Sequence: KLKPLEVELR RLEDLSESIV NDFAYMKKRE EEMRDTNEST NTRVLYFSIF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TMED10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMED10

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 219 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TMED10

Target: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Alternative Name: TMED10

Background: TMED10 is involved in vesicular protein trafficking.This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.
Alias Symbols: P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23
Protein Interaction Partner: UBC, SUMO1, NEDD8, ASB8, RNF2, FBXO6, rev, TMED9, COPZ1, SEC23B, UBL4A, DHODH, ATF2, VCP, PTRF, S100A16, NIT2, PRDX6, SEC22B, EIF3C, VAMP2, COPG1, COPE, COPB2, COPB1, COPA, ARCN1, CDK2, EBNA-LP, RYK, TMED2, PSENEN, APH1A, NCSTN, ARF1, GORASP2,
Protein Size: 219

Molecular Weight: 24 kDa

Gene ID: 10972

NCBI Accession: NM_006827, NP_006818

UniProt: P49755