SHB antibody (N-Term)

Catalog No. ABIN2787818

The Rabbit Polyclonal anti-SHB antibody (ABIN2787818) specifically detects SHB in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Rabbit and Dog samples.

Quick Overview for SHB antibody (N-Term) (ABIN2787818)

Target: SHB (Src Homology 2 Domain Containing Adaptor Protein B (SHB))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SHB Antibody

Binding Specificity: N-Term

Sequence: ERPSQPPQAV PQASSAASAS CGPATASCFS ASSGSLPDDS GSTSDLIRAY

Predicted Reactivity: Cow: 100%, Dog: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SHB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SHB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 509 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SHB

Target: SHB (Src Homology 2 Domain Containing Adaptor Protein B (SHB))

Alternative Name: SHB

Background: SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Alias Symbols: RP11-3J10.8, bA3J10.2
Protein Interaction Partner: SLC39A1, GRAP2, LAT, LCP2, EPS8, JAK3, IL2RG, KDR, SRC, ZAP70, PDGFRA, PLCG1, PIK3R1, VAV1, CRK, JAK1, IL2RB, GRB2, FGFR1, PDGFRB,
Protein Size: 509

Molecular Weight: 55 kDa

Gene ID: 6461

NCBI Accession: NM_003028, NP_003019

UniProt: Q15464