ATG4B antibody (N-Term)

Catalog No. ABIN2787882

This anti-ATG4B antibody is a Rabbit Polyclonal antibody detecting ATG4B in WB. Suitable for Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Guinea Pig, Rabbit, Cow and Horse.

Quick Overview for ATG4B antibody (N-Term) (ABIN2787882)

Target: ATG4B (Autophagy related 4B Cysteine Peptidase (ATG4B))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Guinea Pig, Rabbit, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG4B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATG4B Antibody

Binding Specificity: N-Term

Sequence: SVLNAFIDRK DSYYSIHQIA QMGVGEGKSI GQWYGPNTVA QVLKKLAVFD

Predicted Reactivity: Cow: 86%, Dog: 100%, Guinea Pig: 93%, Horse: 77%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against ATG4B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATG4B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 393 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATG4B

Target: ATG4B (Autophagy related 4B Cysteine Peptidase (ATG4B))

Alternative Name: ATG4B

Background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. APG4B encodes a member of the autophagin protein family and is also designated as a member of the C-54 family of cysteine proteases.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: APG4B, AUTL1, MGC1353
Protein Interaction Partner: SUMO2, MAP1LC3B, MAP1LC3A, BAG3, ATG8, YWHAB, GABARAPL1, SQSTM1, UBC, GABARAPL2, ATG10, ATG3, AMBRA1, GABARAP, CAMKK2, ATG12, ULK1, STK3, KRT4, ANXA1, FBXW11, LINC00341,
Protein Size: 393

Molecular Weight: 44 kDa

Gene ID: 23192

NCBI Accession: NM_013325, NP_037457

UniProt: Q9Y4P1

Pathways: Autophagy