Presenilin 1 antibody (Middle Region)

Catalog No. ABIN2787886

The Rabbit Polyclonal anti-Presenilin 1 antibody has been validated for WB, IHC and IP. It is suitable to detect Presenilin 1 in samples from Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse and Rabbit.

Quick Overview for Presenilin 1 antibody (Middle Region) (ABIN2787886)

Target: Presenilin 1 (PSEN1)

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-Presenilin 1 Antibody

Binding Specificity: Middle Region

Sequence: EGDPEAQRRV SKNSKYNAES TERESQDTVA ENDDGGFSEE WEAQRDSHLG

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against PSEN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSEN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 467 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Alias Symbols: AD3, FAD, PS1, S182, PS-1
Protein Interaction Partner: UBC, TRAF6, TGFBR1, ERLIN2, PSMB1, PSMA5, ETFA, TDP2, PSEN2, PSEN1, APH1B, PSENEN, APH1A, NCSTN, ITSN2, PDCD4, KANK2, EPB41L3, CDC37, TUBA1B, AP1M2, UMPS, PRDX2, ST13, SCN1A, RHEB, RAD23A, RAB3A, OXCT1, NOS3, NDUFS8, HMGB1, GCDH, GAPDH, FGF13, ENSA, DTNA,
Protein Size: 467

Molecular Weight: 53 kDa

Gene ID: 5663

NCBI Accession: NM_000021, NP_000012

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport