TIMP2 antibody (N-Term)

Catalog No. ABIN2787967

This anti-TIMP2 antibody is a Rabbit Polyclonal antibody detecting TIMP2 in WB and IHC. Suitable for Human, Rat, Mouse, Cow, Zebrafish (Danio rerio), Rabbit, Guinea Pig, Dog, Horse and Sheep.

Quick Overview for TIMP2 antibody (N-Term) (ABIN2787967)

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reactivity: Human, Rat, Mouse, Cow, Zebrafish (Danio rerio), Rabbit, Guinea Pig, Dog, Horse, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TIMP2 Antibody

Binding Specificity: N-Term

Sequence: NADVVIRAKA VSEKEVDSGN DIYGNPIKRI QYEIKQIKMF KGPEKDIEFI

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against TIMP2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TIMP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 220 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Alternative Name: TIMP2

Background: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Alias Symbols: CSC-21K, Metalloproteinase inhibitor 2, TIMP2, TIMP metallopeptidase inhibitor 2, Tissue inhibitor of metalloproteinases 2, Timp2
Protein Interaction Partner: BAG3, ITGA3, MMP14, ITGB1, MMP2, MMP8, SNCG, PSMA7,
Protein Size: 220

Molecular Weight: 22 kDa

Gene ID: 7077

NCBI Accession: NM_003255, NP_003246

UniProt: P16035

Pathways: cAMP Metabolic Process