PEN2 antibody (N-Term)

Catalog No. ABIN2788067

This anti-PEN2 antibody is a Rabbit Polyclonal antibody detecting PEN2 in WB. Suitable for Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit and Zebrafish (Danio rerio).

Quick Overview for PEN2 antibody (N-Term) (ABIN2788067)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PEN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PEN2 Antibody

Binding Specificity: N-Term

Sequence: LGGFAFLPFL WLVNIFWFFR EAFLAPAYTE QSQIKGYVWR SAVGFLFWVI

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against Psenen. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 101 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Alternative Name: Psenen

Background: Psenen is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Alias Symbols: 1700023M09Rik, MGC102026
Protein Interaction Partner: Psen2, Psen1,
Protein Size: 101

Molecular Weight: 12 kDa

Gene ID: 66340

NCBI Accession: NM_025498, NP_079774

UniProt: Q9CQR7

Pathways: Notch Signaling, Neurotrophin Signaling Pathway