SPR antibody (C-Term)

Catalog No. ABIN2788144

This anti-SPR antibody is a Rabbit Polyclonal antibody detecting SPR in WB. Suitable for Human, Mouse, Rat, Dog, Horse and Rabbit.

Quick Overview for SPR antibody (C-Term) (ABIN2788144)

Target: SPR (Sepiapterin Reductase (SPR))

Reactivity: Human, Mouse, Rat, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPR Antibody

Binding Specificity: C-Term

Sequence: ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF KSGAHVDFYD

Predicted Reactivity: Dog: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 86%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SPR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SPR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 261 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: SPR

Background: This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
Alias Symbols: SDR38C1
Protein Interaction Partner: UBC, YWHAQ, MRPL53, SRPRB, SUGP1, SBDS, AHCYL1, SCO2, RAD23B, PPM1G, NDUFA2, IDH3G, CRK, ASS1, CAMK2G,
Protein Size: 261

Molecular Weight: 28 kDa

Gene ID: 6697

NCBI Accession: NM_003124, NP_003115

UniProt: P35270

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration