GRK1 antibody (Middle Region)

Catalog No. ABIN2788207

Product Details anti-GRK1 Antibody

Target: GRK1 (G Protein-Coupled Receptor Kinase 1 (GRK1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NKELKHRIIS EPVKYPDKFS QASKDFCEAL LEKDPEKRLG FRDETCDKLR

Predicted Reactivity: Cow: 92%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 79%, Rat: 93%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against GRK1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GRK1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 563 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GRK1

Target: GRK1 (G Protein-Coupled Receptor Kinase 1 (GRK1))

Alternative Name: GRK1 (GRK1 Products)

Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
Alias Symbols: GPRK1, RHOK, RK
Protein Interaction Partner: MYC, PDE6D, CAV1, GRK1, RHO, RCVRN, CALM1, SNCG, SNCA, SNCB,
Protein Size: 563

Molecular Weight: 63 kDa

Gene ID: 6011

NCBI Accession: NM_002929, NP_002920

UniProt: Q15835

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction