Angiotensin II Type 2 Receptor antibody (N-Term)

Catalog No. ABIN2788290

Product Details anti-Angiotensin II Type 2 Receptor Antibody

Target: Angiotensin II Type 2 Receptor (AGTR2) (Angiotensin II Receptor, Type 2 (AGTR2))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiotensin II Type 2 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LHFGLVNISG NNESTLNCSQ KPSDKHLDAI PILYYIIFVI GFLVNIVVVT

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 79%, Human: 100%, Mouse: 79%, Pig: 86%, Rabbit: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against AGTR2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AGTR2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 363 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Angiotensin II Type 2 Receptor

Target: Angiotensin II Type 2 Receptor (AGTR2) (Angiotensin II Receptor, Type 2 (AGTR2))

Alternative Name: AGTR2 (AGTR2 Products)

Synonyms: AT2 antibody, ATGR2 antibody, MRX88 antibody, AI316812 antibody, AW107640 antibody, AT2-R antibody, AT2R antibody, AT₂R antibody, at2 antibody, zgc:113016 antibody, AGTR2 antibody, angiotensin II receptor type 2 antibody, angiotensin II receptor, type 2 antibody, AGTR2 antibody, Agtr2 antibody, agtr2 antibody

Background: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation.
Alias Symbols: AT2, ATGR2, MRX88
Protein Interaction Partner: ERBB2IP, TIMP3, SNTA1, ZBTB16, MTUS1, PIK3CB, ERBB3, GNAI3, GNAI2, ACE, AGT, AGTRAP,
Protein Size: 363

Molecular Weight: 41 kDa

Gene ID: 186

NCBI Accession: NM_000686, NP_000677

UniProt: P50052

Pathways: ACE Inhibitor Pathway, Hormone Transport, Regulation of Systemic Arterial Blood Pressure by Hormones