MAPKAP Kinase 2 antibody (Middle Region)

Catalog No. ABIN2788401

The Rabbit Polyclonal anti-MAPKAP Kinase 2 antibody has been validated for WB and IHC. It is suitable to detect MAPKAP Kinase 2 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig and Horse.

Quick Overview for MAPKAP Kinase 2 antibody (Middle Region) (ABIN2788401)

Target: MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP Kinase 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MAPKAP Kinase 2 Antibody

Binding Specificity: Middle Region

Sequence: KLTDFGFAKE TTQNALQTPC YTPYYVAPEV LGPEKYDKSC DMWSLGVIMY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against MAPKAPK2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MAPKAPK2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 370 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAPKAP Kinase 2

Target: MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))

Alternative Name: MAPKAPK2

Background: MAPKAPK2 is a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo.
Alias Symbols: 3PK, MAPKAP3, MK2, MK-2, MAPKAP-K2
Protein Interaction Partner: PIAS2, DDX5, MAPK14, AKT1, HSPB1, MAPKAPK2, UBC, Ube2j1, TCF3, DES, MAP2K6, MAPK11, MAPK3, PABPC1, HNRNPA0, PARN, LIMK1, HSF1, CHEK1, CDC25B, ALOX5, ZFP36L1, ESR1, COPS5, CUL3, MAPKAPK5, MAPK1, ELAVL1, PHC2, CSNK2B, ARPC5, EEF2K, BAG2, YWHAZ, SRF, SHC1, E
Protein Size: 370

Molecular Weight: 42 kDa

Gene ID: 9261

NCBI Accession: NM_004635, NP_004626

UniProt: Q16644

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades