TPR antibody (C-Term)

Catalog No. ABIN2788674

This Rabbit Polyclonal antibody specifically detects TPR in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig and Horse.

Quick Overview for TPR antibody (C-Term) (ABIN2788674)

Target: TPR (Nucleoprotein TPR (TPR))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TPR Antibody

Binding Specificity: C-Term

Sequence: SSEAGLEIDS QQEEEPVQAS DESDLPSTSQ DPPSSSSVDT SSSQPKPFRR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TPR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TPR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2363 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TPR

Target: TPR (Nucleoprotein TPR (TPR))

Alternative Name: TPR

Background: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias.
Alias Symbols: -
Protein Interaction Partner: STAU1, UBC, LGR4, MDM2, MAD1L1, EED, NPM1, LMNA, HDAC9, ITGA4, FN1, CBX7, BUD31, TAF15, TOP1, SNRPD1, SNRPA1, SRSF5, SFPQ, S100A9, RPL37A, RPL18A, RPL6, RBM4, RAN, PRKDC, NHP2L1, SEPT2, IK, HRAS, HNRNPU, HNRNPA2B1, EEF1D, EEF1B2, DDX3X, DDX1, DDB1, CIRBP,
Protein Size: 2363

Molecular Weight: 267 kDa

Gene ID: 7175

NCBI Accession: NM_003292, NP_003283

UniProt: P12270