Clusterin antibody (C-Term)

Catalog No. ABIN2788692

This Rabbit Polyclonal antibody specifically detects Clusterin in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Horse and Guinea Pig.

Quick Overview for Clusterin antibody (C-Term) (ABIN2788692)

Target: Clusterin (CLU)

Reactivity: Human, Rat, Mouse, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Clusterin Antibody

Binding Specificity: C-Term

Sequence: CREILSVDCS TNNPSQAKLR RELDESLQVA ERLTRKYNEL LKSYQWKMLN

Predicted Reactivity: Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 91%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against CLU. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CLU

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 501 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: CLU

Background: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.
Alias Symbols: AAG4, APOJ, CLI, KUB1, MGC24903, SGP-2, SGP2, SP-40, APO-J, NA1/NA2
Protein Interaction Partner: HYOU1, HSP90B1, HSPA5, BAX, TUFM, NUCB2, HSPA1L, TUBB6, MDM2, FOS, CDK19, APOA1, KEAP1, POLR1C, RPL23, KLF11, BAG6, RBBP8, MAPK9, PDIA3, CYP2E1, BCL2L1, TSC22D4, MDC1, LIG4, PAXIP1, CLUAP1, IL24, PRNP, PON1, HSPD1, APP, FBXO6, LYZ, LRP2, HBA1, XRCC6, ELN,
Protein Size: 501

Molecular Weight: 58 kDa

Gene ID: 1191

NCBI Accession: NM_001831, NP_001822

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling