RCC1 antibody (C-Term)

Catalog No. ABIN2788760

The Rabbit Polyclonal anti-RCC1 antibody (ABIN2788760) specifically detects RCC1 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio) samples.

Quick Overview for RCC1 antibody (C-Term) (ABIN2788760)

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RCC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RCC1 Antibody

Binding Specificity: C-Term

Sequence: AWGMGTNYQL GTGQDEDAWS PVEMMGKQLE NRVVLSVSSG GQHTVLLVKD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against RCC1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 421 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RCC1

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Alternative Name: RCC1

Background: RCC1 is a Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
Alias Symbols: CHC1, RCC1-I, SNHG3-RCC1
Protein Interaction Partner: UBC, SUMO2, SUMO1, NEDD8, MDM2, SUZ12, RNF2, PTMA, HDAC9, HMGA1, VCAM1, ITGA4, FN1, U2AF1, RANBP1, RAN, HNRNPM, HNRNPK, LUC7L3, SF3B6, NCSTN, ACIN1, RBM14, HDGF, SPRED1, FLAD1, WIZ, LRIF1, CSAD, SDF4, TRMT2A, DDAH2, FAF1, NUDT21, CCT7, TUBB3, CDK2AP2, KMT
Protein Size: 421

Molecular Weight: 45 kDa

Gene ID: 1104

NCBI Accession: NM_001269, NP_001260

UniProt: P18754

Pathways: Chromatin Binding, Protein targeting to Nucleus