RCC1 antibody (C-Term)

Catalog No. ABIN2788760

This anti-RCC1 antibody is a Rabbit Polyclonal antibody detecting RCC1 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for RCC1 antibody (C-Term) (ABIN2788760)

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RCC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RCC1 Antibody

Binding Specificity: C-Term

Sequence: AWGMGTNYQL GTGQDEDAWS PVEMMGKQLE NRVVLSVSSG GQHTVLLVKD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against RCC1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 421 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RCC1

Target: RCC1 (Regulator of Chromosome Condensation 1 (RCC1))

Alternative Name: RCC1

Background: RCC1 is a Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
Alias Symbols: CHC1, RCC1-I, SNHG3-RCC1
Protein Interaction Partner: UBC, SUMO2, SUMO1, NEDD8, MDM2, SUZ12, RNF2, PTMA, HDAC9, HMGA1, VCAM1, ITGA4, FN1, U2AF1, RANBP1, RAN, HNRNPM, HNRNPK, LUC7L3, SF3B6, NCSTN, ACIN1, RBM14, HDGF, SPRED1, FLAD1, WIZ, LRIF1, CSAD, SDF4, TRMT2A, DDAH2, FAF1, NUDT21, CCT7, TUBB3, CDK2AP2, KMT
Protein Size: 421

Molecular Weight: 45 kDa

Gene ID: 1104

NCBI Accession: NM_001269, NP_001260

UniProt: P18754

Pathways: Chromatin Binding, Protein targeting to Nucleus