WWOX antibody (C-Term)

Catalog No. ABIN2788787

This Rabbit Polyclonal antibody specifically detects WWOX in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig and Rabbit.

Quick Overview for WWOX antibody (C-Term) (ABIN2788787)

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWOX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WWOX Antibody

Binding Specificity: C-Term

Sequence: DDNPTKPTTR QRYDGSTTAM EILQGRDFTG KVVVVTGANS GIGFETAKSF

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against WWOX. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 189 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Alternative Name: WWOX

Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90 % identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
Alias Symbols: D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Protein Interaction Partner: ITCH, TRIM28, HUWE1, UBC, ATM, RPRD2, CYFIP1, SPG20, SNRNP200, ACIN1, SLC4A1AP, DHX30, SCAF8, XRN2, GABARAPL2, SEC23IP, HNRNPUL1, DIDO1, CPSF6, SF3B2, SF3A3, SRSF10, USP39, IGF2BP2, IGF2BP3, IGF2BP1, PAICS, PRPF8, CCT2, CCT7, NOP56, DDX17, SEC23A, BAIAP2,
Protein Size: 189

Molecular Weight: 21 kDa

Gene ID: 51741

NCBI Accession: NM_130791, NP_570607