UBE2V1 antibody (N-Term)

Catalog No. ABIN2788879

The Rabbit Polyclonal anti-UBE2V1 antibody has been validated for WB. It is suitable to detect UBE2V1 in samples from Human.

Quick Overview for UBE2V1 antibody (N-Term) (ABIN2788879)

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2V1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UBE2V1 Antibody

Binding Specificity: N-Term

Sequence: GEVQASYLKS QSKLSDEGRL EPRKFHCKGV KVPRNFRLLE ELEEGQKGVG

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against UBE2V1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 170 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UBE2V1

Target: UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1))

Alternative Name: UBE2V1

Background: Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Alias Symbols: CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A
Protein Interaction Partner: UBC, TRAF6, ube2nb, UBQLN1, FAM168A, TRAF3IP2, STUB1, PARK2, TXNDC5, YWHAQ, ECHS1, YWHAZ, YWHAG, TGM2, LDHB, SFN, G6PD, IQCB1, PELI3, ULK4, POMP, UBXN7, UBE2C, AHCYL1, SSSCA1, UBE4B, TTC9C, ATP6V1G1, ATP6V1F, ZYX, UGDH, UCHL3, UBE2V2, UBE2N, UBE2D2, UBE2B
Protein Size: 170

Molecular Weight: 19 kDa

Gene ID: 7335

NCBI Accession: NM_021988, NP_068823

UniProt: Q13404

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades