RPL7A antibody (C-Term)

Catalog No. ABIN2788883

The Rabbit Polyclonal anti-RPL7A antibody has been validated for WB. It is suitable to detect RPL7A in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for RPL7A antibody (C-Term) (ABIN2788883)

Target: RPL7A (Ribosomal Protein L7a (RPL7A))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPL7A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RPL7A Antibody

Binding Specificity: C-Term

Sequence: KLVEAIRTNY NDRYDEIRRH WGGNVLGPKS VARIAKLEKA KAKELATKLG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against RPL7A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 266 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RPL7A

Target: RPL7A (Ribosomal Protein L7a (RPL7A))

Alternative Name: RPL7A

Background: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Alias Symbols: SURF3, TRUP, L7A
Protein Interaction Partner: HUWE1, UBC, TP53, SUMO2, CEP250, STAU1, MDM2, EED, RNF2, EEF1E1, AIMP1, DARS, RPL36, RPLP0, RPL26, RPL23A, RPL21, RPL15, RPL13, QARS, EIF2S1, TRAP1, PARK2, FBXO6, TARDBP, IGSF8, ICAM1, PAN2, SOCS3, UBL4A, VCAM1, ITGA4, FN1, CTBP2, MAGOH, EIF4A3, UPF1, ESR
Protein Size: 266

Molecular Weight: 29 kDa

Gene ID: 6130

NCBI Accession: NM_000972, NP_000963

UniProt: P62424