Cyclin-Dependent Kinase 11A (CDK11A) (C-Term) antibody

Catalog No. ABIN2788912

This Rabbit Polyclonal antibody specifically detects in WB. It exhibits reactivity toward Human, Mouse, Dog, Rat, Cow, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for Cyclin-Dependent Kinase 11A (CDK11A) (C-Term) antibody (ABIN2788912)

Target: Cyclin-Dependent Kinase 11A (CDK11A)

Reactivity: Human, Mouse, Dog, Rat, Cow, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: C-Term

Sequence: EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CDK11A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 767 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Cyclin-Dependent Kinase 11A (CDK11A)

Alternative Name: CDK11A

Background: This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.
Alias Symbols: CDC2L2, CDC2L3, p58GTA, PITSLRE, CDK11-p46, CDK11-p58, CDK11-p110
Protein Interaction Partner: UBC, CDC37, FKBP5, PIN1, CDK11A, HKR1, C18orf25, RBM25, ZFP14, PRPF40A, NOP58, ZNF510, ZNF460, ZNF267, ZNF33A, PSMD1, KPNA2, KPNB1, CSNK2B, CSNK2A2, CSNK2A1, CDKN2A, A2M, SOX2, Dlg4, GADD45A, HSP90AA1, SMAD3, SUMO2, CCNL1, SRSF7, RNPS1, KAT7, PAK1, CASP8,
Protein Size: 767

Molecular Weight: 84 kDa

Gene ID: 728642

NCBI Accession: NM_033529, NP_277071

UniProt: Q9UQ88

Pathways: M Phase