MCC antibody (C-Term)

Catalog No. ABIN2789347

This anti-MCC antibody is a Rabbit Polyclonal antibody detecting MCC in WB and IHC. Suitable for Human, Mouse, Rat, Guinea Pig, Horse and Dog.

Quick Overview for MCC antibody (C-Term) (ABIN2789347)

Target: MCC (Mutated in Colorectal Cancers (MCC))

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MCC Antibody

Binding Specificity: C-Term

Sequence: SSTSSGSKDK PGKECADAAS PALSLAELRT TCSENELAAE FTNAIRREKK

Predicted Reactivity: Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against MCC. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 829 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MCC

Target: MCC (Mutated in Colorectal Cancers (MCC))

Alternative Name: MCC

Background: This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DKFZp762O1615, FLJ38893, FLJ46755, MCC1
Protein Interaction Partner: CSNK1E, ERBB2IP, CBX5, GTF2E2, APP, DYNC1I1, NEK2, NFKBIB, STRIP1, VPS35, STRN3, STRN4, SNRNP200, PDCD10, PAICS, PSME3, CCNA1, EIF3A, STK24, EZR, VHL, VDAC1, VCP, TPM3, TARS, STRN, PSMD2, PPP2R1A, PFKP, PFAS, MYH10, MTHFD1, MARS, LTA4H, KRT18, IARS, HPRT1
Protein Size: 829

Molecular Weight: 91 kDa

Gene ID: 4163

NCBI Accession: NM_002387, NP_002378