MCC antibody (AA 479-611)

Catalog No. ABIN7148294

Product Details anti-MCC Antibody

Target: MCC (Mutated in Colorectal Cancers (MCC))

Binding Specificity: AA 479-611

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCC antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Colorectal mutant cancer protein (479-611AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MCC

Target: MCC (Mutated in Colorectal Cancers (MCC))

Alternative Name: MCC (MCC Products)

Synonyms: MCC antibody, mcc1 antibody, MCC1 antibody, D18Ertd451e antibody, E330037C19 antibody, RGD1561988 antibody, mutated in colorectal cancers antibody, MCC antibody, mcc antibody, Mcc antibody

Background:

Background: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).

Aliases: Colorectal mutant cancer protein antibody, CRCM_HUMAN antibody, DKFZp762O1615 antibody, FLJ38893 antibody, FLJ46755 antibody, MCC 1 antibody, MCC antibody, MCC1 antibody, Mutated in colorectal cancers antibody, Protein MCC antibody

UniProt: P23508