BMP4 antibody (N-Term)

Catalog No. ABIN2789355

This Rabbit Polyclonal antibody specifically detects BMP4 in WB. It exhibits reactivity toward Human, Rat, Mouse, Rabbit, Cow, Sheep, Dog, Goat, Guinea Pig and Horse.

Quick Overview for BMP4 antibody (N-Term) (ABIN2789355)

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Reactivity: Human, Rat, Mouse, Rabbit, Cow, Sheep, Dog, Goat, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BMP4 Antibody

Binding Specificity: N-Term

Sequence: HASLIPETGK KKVAEIQGHA GGRRSGQSHE LLRDFEATLL QMFGLRRRPQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against BMP4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 408 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BMP4

Target: BMP4 (Bone Morphogenetic Protein 4 (BMP4))

Alternative Name: BMP4

Background: The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Alias Symbols: BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
Protein Interaction Partner: BMPR2, ZFYVE9, UBC, BGN, GREM2, BMPER, SOSTDC1, CHRDL2, STAP2, BMPR1B, NOG, BMP8B, HTRA1, BMPR1A, CHRDL1, BMP4, TWSG1, CHRD,
Protein Size: 408

Molecular Weight: 45 kDa

Gene ID: 652

NCBI Accession: NM_130850, NP_570911

UniProt: P12644

Pathways: Steroid Hormone Mediated Signaling Pathway, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development