PLAUR antibody (N-Term)

Catalog No. ABIN2789360

This Rabbit Polyclonal antibody specifically detects PLAUR in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for PLAUR antibody (N-Term) (ABIN2789360)

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAUR antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PLAUR Antibody

Binding Specificity: N-Term

Sequence: ELELVEKSCT HSEKTNRTLS YRTGLKITSL TEVVCGLDLC NQGNSGRAVT

Predicted Reactivity: Human: 100%, Mouse: 82%

Characteristics: This is a rabbit polyclonal antibody against PLAUR. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of PLAUR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 335 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLAUR

Target: PLAUR (Plasminogen Activator, Urokinase Receptor (PLAUR))

Alternative Name: PLAUR

Background: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Alias Symbols: CD87, UPAR, URKR
Protein Interaction Partner: TEX101, PLAU, LYN, ELAVL1, VMA21, TXNDC17, SCAF4, SDHAF2, UBQLN2, WDHD1, SELENBP1, TBCA, PSAP, CTSA, OXCT1, NOTCH2, HDLBP, CTTN, LRP1B, SURF2, SRPX2, MMP12, IL6ST, FAP, KNG1, VTN, TYK2, PFN2, JAK1, HCK, FYN, ITGB1, EEF1A1, ITGAM, LRP1, IGF2R, ITGB2, PDGFR
Protein Size: 335

Molecular Weight: 37 kDa

Gene ID: 5329

NCBI Accession: NM_002659, NP_002650

UniProt: Q9GK80

Pathways: Inositol Metabolic Process