TFPI antibody (Middle Region)

Catalog No. ABIN2789367

The Rabbit Polyclonal anti-TFPI antibody (ABIN2789367) specifically detects TFPI in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Rabbit, Guinea Pig, Dog, Horse, Pig and Cow samples.

Quick Overview for TFPI antibody (Middle Region) (ABIN2789367)

Target: TFPI (Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI))

Reactivity: Human, Rat, Mouse, Rabbit, Guinea Pig, Dog, Horse, Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFPI antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TFPI Antibody

Binding Specificity: Middle Region

Sequence: QEKPDFCFLE EDPGICRGYI TRYFYNNQTK QCERFKYGGC LGNMNNFETL

Predicted Reactivity: Cow: 86%, Dog: 77%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against TFPI. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 304 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TFPI

Target: TFPI (Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI))

Alternative Name: TFPI

Background: This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
Alias Symbols: EPI, LACI, TFI, TFPI1
Protein Interaction Partner: SMU1, SF3B1, BCAS2, SAP18, SRSF11, SON, SRSF7, APP, ELAVL1, PRSS3, MMP12, F10, THBS1, MMP7, ELANE, MMP9, MMP8, MMP1,
Protein Size: 304

Molecular Weight: 33 kDa

Gene ID: 7035

NCBI Accession: NM_006287, NP_006278

UniProt: P10646