DRD3 antibody (C-Term)

Catalog No. ABIN2789395

The Rabbit Polyclonal anti-DRD3 antibody has been validated for WB. It is suitable to detect DRD3 in samples from Human, Rat, Dog, Horse, Pig, Cow and Guinea Pig.

Quick Overview for DRD3 antibody (C-Term) (ABIN2789395)

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Reactivity: Human, Rat, Dog, Horse, Pig, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DRD3 Antibody

Binding Specificity: C-Term

Sequence: QERGGELKRE EKTRNSLMPL REKKATQMVA IVLGAFIVCW LPFFLTHVLN

Predicted Reactivity: Cow: 77%, Dog: 86%, Guinea Pig: 75%, Horse: 79%, Human: 100%, Pig: 79%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against DRD3. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 367 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DRD3

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Alternative Name: DRD3

Background: This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
Alias Symbols: D3DR, ETM1, FET1, MGC149204, MGC149205
Protein Interaction Partner: SLC9A3, USP48, EEF1G, CLIC6, MPDZ, EPB41L2, GIPC1, NCS1, EPB41L1, EEF1B2, NCK1, FLNA, GNAI1, EPB41, GRB2, RDX,
Protein Size: 367

Molecular Weight: 41 kDa

Gene ID: 1814

NCBI Accession: NM_033663, NP_387512

UniProt: P35462

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity