ABI1 antibody (C-Term)

Catalog No. ABIN2789495

The Rabbit Polyclonal anti-ABI1 antibody has been validated for WB. It is suitable to detect ABI1 in samples from Human, Rat, Mouse, Horse, Rabbit, Cow, Guinea Pig, Dog and Zebrafish (Danio rerio).

Quick Overview for ABI1 antibody (C-Term) (ABIN2789495)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reactivity: Human, Rat, Mouse, Horse, Rabbit, Cow, Guinea Pig, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABI1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ABI1 Antibody

Binding Specificity: C-Term

Sequence: IEKVVAIYDY TKDKDDELSF MEGAIIYVIK KNDDGWYEGV CNRVTGLFPG

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against ABI1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 388 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: ABI1

Background: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Alias Symbols: ABI-1, E3B1, NAP1BP, SSH3BP, SSH3BP1, ABLBP4
Protein Interaction Partner: ABL1, UBC, PRPF40A, TCERG1, GAS7, APBB1, SRRM1, PRKAA1, PIK3R1, CDC123, CTTN, NCK2, NCK1, CBL, CACNA1A, RYK, EPS8L1, ENAH, MINK1, EVL, NIN, CYFIP2, HSPA8, WASF2, WASF1, PAK2, NCKAP1, ABI1, VASP, SOS2, EPS8, NCF1, SPTA1, SPTAN1, SOS1, NEB, EPS8L3, EPS8L2,
Protein Size: 388

Molecular Weight: 42 kDa

Gene ID: 10006

NCBI Accession: NM_001178124, NP_001171595

UniProt: B6VEX5

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling