Sclerostin antibody (N-Term)

Catalog No. ABIN2789538

This Rabbit Polyclonal antibody specifically detects Sclerostin in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Dog, Pig, Horse, Cow and Guinea Pig.

Quick Overview for Sclerostin antibody (N-Term) (ABIN2789538)

Target: Sclerostin (SOST)

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Pig, Horse, Cow, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sclerostin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Sclerostin Antibody

Binding Specificity: N-Term

Sequence: PELGEYPEPP PELENNKTMN RAENGGRPPH HPFETKDVSE YSCRELHFTR

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SOST. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 213 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Sclerostin

Target: Sclerostin (SOST)

Alternative Name: SOST

Background: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Alias Symbols: VBCH
Protein Interaction Partner: LRP6, LRP5,
Protein Size: 213

Molecular Weight: 23 kDa

Gene ID: 50964

NCBI Accession: NM_025237, NP_079513

UniProt: Q9BQB4