Sclerostin antibody (N-Term)
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- Target See all Sclerostin (SOST) Antibodies
- Sclerostin (SOST)
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Rabbit, Dog, Pig, Horse, Cow, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Sclerostin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- PELGEYPEPP PELENNKTMN RAENGGRPPH HPFETKDVSE YSCRELHFTR
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against SOST. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product SOST Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 213 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Sclerostin (SOST)
- Alternative Name
- SOST (SOST Products)
- Synonyms
- LOC100313724 antibody, CDD antibody, VBCH antibody, 5430411E23Rik antibody, sclerostin antibody, LOC100313724 antibody, SOST antibody, Sost antibody
- Background
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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Alias Symbols: VBCH
Protein Interaction Partner: LRP6, LRP5,
Protein Size: 213 - Molecular Weight
- 23 kDa
- Gene ID
- 50964
- NCBI Accession
- NM_025237, NP_079513
- UniProt
- Q9BQB4
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