Transferrin Receptor antibody (N-Term)

Catalog No. ABIN2789600

This anti-Transferrin Receptor antibody is a Rabbit Polyclonal antibody detecting Transferrin Receptor in WB and IHC. Suitable for Human and Rabbit.

Quick Overview for Transferrin Receptor antibody (N-Term) (ABIN2789600)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivity: Human, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Transferrin Receptor Antibody

Binding Specificity: N-Term

Sequence: PVREEPGEDF PAARRLYWDD LKRKLSEKLD STDFTGTIKL LNENSYVPRE

Predicted Reactivity: Human: 100%, Rabbit: 91%

Characteristics: This is a rabbit polyclonal antibody against TFRC. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 760 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: TFRC

Background: TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Alias Symbols: CD71, TFR, TFR1, TRFR, T9, TR, p90
Protein Interaction Partner: HUWE1, UBC, SGTA, CAV1, TP53, RAB8A, RANBP9, LGR4, MDM2, RPA3, RPA2, RPA1, ASB4, RNF2, OPTN, ADRB2, CLN3, MARCH8, env, MARCH1, MYO1G, VCAM1, ITGA4, FN1, ATF2, B4GALT1, ESR1, ATP6V1B1, FBXO6, KCNA5, KCNA3, vpu, SH3BP4, PARK2, LAPTM4B, LAPTM4A, HGS, SUMO2,
Protein Size: 760

Molecular Weight: 84 kDa

Gene ID: 7037

NCBI Accession: NM_003234, NP_003225

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis