MASP1 antibody (N-Term)

Catalog No. ABIN2789651

This Rabbit Polyclonal antibody specifically detects MASP1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog and Horse.

Quick Overview for MASP1 antibody (N-Term) (ABIN2789651)

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MASP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MASP1 Antibody

Binding Specificity: N-Term

Sequence: PGSFMSITFR SDFSNEERFT GFDAHYMAVD VDECKEREDE ELSCDHYCHN

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MASP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MASP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 699 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MASP1

Target: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Alternative Name: MASP1

Background: This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.
Alias Symbols: CRARF, CRARF1, DKFZp686I01199, FLJ26383, MASP, MGC126283, MGC126284, PRSS5, RaRF
Protein Interaction Partner: CDK19, CUL3, PDCD6IP, RPS6KA6, MAPK8IP2, NUDT21, NCK2, UFD1L, RPS6KA3, MAPK6, H2AFX, GSK3B, GADD45A, C2, SERPING1, FCN2, MBL2, C3, MASP2,
Protein Size: 699

Molecular Weight: 28 kDa

Gene ID: 5648

NCBI Accession: NM_001879, NP_001870

UniProt: P48740

Pathways: Complement System