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WISP1 antibody (Middle Region)

WISP1 Reactivity: Human, Pig, Cow WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2789653
  • Target See all WISP1 Antibodies
    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
    Binding Specificity
    • 15
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 40
    • 26
    • 4
    • 1
    • 1
    • 1
    • 1
    Human, Pig, Cow
    Host
    • 54
    • 5
    • 1
    • 1
    Rabbit
    Clonality
    • 57
    • 4
    Polyclonal
    Conjugate
    • 26
    • 9
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This WISP1 antibody is un-conjugated
    Application
    • 35
    • 21
    • 20
    • 13
    • 13
    • 8
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    VRPPRLWCPH PRRVSIPGHC CEQWVCEDDA KRPRKTAPRD TGAFDAVGEV
    Predicted Reactivity
    Cow: 92%, Human: 100%, Pig: 85%
    Characteristics
    This is a rabbit polyclonal antibody against WISP1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Top Product
    Discover our top product WISP1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 367 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
    Alternative Name
    WISP1 (WISP1 Products)
    Synonyms
    CCN4 antibody, WISP1c antibody, WISP1i antibody, WISP1tc antibody, WISP-1 antibody, WISP1 antibody, si:ch211-38f10.2 antibody, AW146261 antibody, Elm1 antibody, zgc:172276 antibody, WNT1 inducible signaling pathway protein 1 antibody, WNT1 inducible signaling pathway protein 1a antibody, WNT1-inducible-signaling pathway protein 1-like antibody, WNT1 inducible signaling pathway protein 1b antibody, WISP1 antibody, wisp1a antibody, Wisp1 antibody, LOC100627044 antibody, wisp1b antibody
    Background
    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.
    Alias Symbols: CCN4, WISP1c, WISP1i, WISP1tc
    Protein Interaction Partner: BGN, DCN, UGGT1,
    Protein Size: 367
    Molecular Weight
    38 kDa
    Gene ID
    8840
    NCBI Accession
    NM_003882, NP_003873
    UniProt
    O95388
    Pathways
    WNT Signaling, Growth Factor Binding
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