CD276 antibody (C-Term)

Catalog No. ABIN2789671

This Rabbit Polyclonal antibody specifically detects CD276 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Pig, Horse, Rabbit, Dog and Guinea Pig.

Quick Overview for CD276 antibody (C-Term) (ABIN2789671)

Target: CD276

Reactivity: Human, Mouse, Rat, Cow, Pig, Horse, Rabbit, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD276 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CD276 Antibody

Binding Specificity: C-Term

Sequence: VCLIALLVAL AFVCWRKIKQ SCEEENAGAE DQDGEGEGSK TALQPLKHSD

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against CD276. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 316 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Background: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: B7-H3, B7H3, B7RP-2, 4Ig-B7-H3
Protein Interaction Partner: UBC, RYK,
Protein Size: 316

Molecular Weight: 34 kDa

Gene ID: 80381

NCBI Accession: NM_025240, NP_079516

Pathways: Cancer Immune Checkpoints