SHANK2 antibody (C-Term)

Catalog No. ABIN2789712

The Rabbit Polyclonal anti-SHANK2 antibody is suitable to detect SHANK2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for SHANK2 antibody (C-Term) (ABIN2789712)

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHANK2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SHANK2 Antibody

Binding Specificity: C-Term

Sequence: PQSPSLNSSQ PTNSADSKKP ASLSNCLPAS FLPPPESFDA VADSGIEEVD

Predicted Reactivity: Cow: 100%, Dog: 85%, Guinea Pig: 77%, Horse: 100%, Human: 100%, Mouse: 85%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against SHANK2. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1254 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SHANK2

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Alternative Name: SHANK2

Background: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.
Alias Symbols: CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3
Protein Interaction Partner: SHARPIN, NLK, LPHN1, DLGAP1, LPHN2, ARHGEF7, BAIAP2, DLG4, BAI2, DNM2, SSTR2, SLC9A3, CTTN, DLGAP3, DLGAP4, DLGAP2, DYNLL2, DYNLL1, MYO5A,
Protein Size: 1254

Molecular Weight: 135 kDa

Gene ID: 22941

NCBI Accession: NM_012309, NP_036441