DUSP4 antibody (C-Term)

Catalog No. ABIN2789728

Product Details anti-DUSP4 Antibody

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GQLLQFESQV LATSCAAEAA SPSGPLRERG KTPATPTSQF VFSFPVSVGV

Predicted Reactivity: Cow: 92%, Dog: 85%, Guinea Pig: 86%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 85%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against DUSP4. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 394 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DUSP4

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Alternative Name: DUSP4 (DUSP4 Products)

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
Alias Symbols: HVH2, MKP-2, MKP2, TYP
Protein Interaction Partner: UBC, MAPK8, MAPK3, APP, CRMP1, GRIN1, MAPK9, GRIN2D, MAPK14, MAPK1,
Protein Size: 394

Molecular Weight: 43 kDa

Gene ID: 1846

NCBI Accession: NM_001394, NP_001385

UniProt: Q13115

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades