UNC13D antibody (C-Term)

Catalog No. ABIN2789769

The Rabbit Polyclonal anti-UNC13D antibody is suitable to detect UNC13D in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig and Horse. It has been validated for WB.

Quick Overview for UNC13D antibody (C-Term) (ABIN2789769)

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC13D antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UNC13D Antibody

Binding Specificity: C-Term

Sequence: SGSEEPGEVP QTRLPLTYPA PNGDPILQLL EGRKGDREAQ VFVRLRRHRA

Predicted Reactivity: Cow: 92%, Dog: 93%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 92%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against UNC13D. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human UNC13D

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UNC13D

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Alternative Name: UNC13D

Background: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alias Symbols: FHL3, HLH3, HPLH3, Munc13-4
Protein Interaction Partner: UBC, CUL5, VPS37B, XRN2, LMNA, RAB27B, RAB27A,
Protein Size: 1090

Molecular Weight: 119 kDa

Gene ID: 201294

NCBI Accession: NM_199242, NP_954712

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process