CDK2AP1 antibody (C-Term)

Catalog No. ABIN2789771

The Rabbit Polyclonal anti-CDK2AP1 antibody has been validated for WB. It is suitable to detect CDK2AP1 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio).

Quick Overview for CDK2AP1 antibody (C-Term) (ABIN2789771)

Target: CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK2AP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK2AP1 Antibody

Binding Specificity: C-Term

Sequence: LLAIIEELGK EIRPTYAGSK SAMERLKRGI IHARGLVREC LAETERNARS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against CDK2AP1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CDK2AP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 115 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDK2AP1

Target: CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))

Alternative Name: CDK2AP1

Background: The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
Alias Symbols: DOC1, DORC1, ST19, doc-1, p12DOC-1
Protein Interaction Partner: MRFAP1L1, CCDC136, HDAC2, HDAC1, ZNF420, MTA3, VCP, CDK2AP2, Cebpb, HHV8GK18_gp81, ELAVL1, MBD3, MBD2, RBBP7, RBBP4, SRRM2, POLA1, CDK2, IGHA2, IGHA1, AMY1A,
Protein Size: 115

Molecular Weight: 12 kDa

Gene ID: 8099

NCBI Accession: NM_004642, NP_004633

UniProt: O14519