S1PR1 antibody (C-Term)

Catalog No. ABIN2789809

The Rabbit Polyclonal anti-S1PR1 antibody (ABIN2789809) specifically detects S1PR1 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Pig, Rabbit, Horse and Guinea Pig samples.

Quick Overview for S1PR1 antibody (C-Term) (ABIN2789809)

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Rabbit, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-S1PR1 Antibody

Binding Specificity: C-Term

Sequence: SLVRTRSRRL TFRKNISKAS RSSEKSLALL KTVIIVLSVF IACWAPLFIL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against S1PR1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 382 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for S1PR1

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Alternative Name: S1PR1

Background: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.
Alias Symbols: CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, FLJ58121, S1P1
Protein Interaction Partner: UBC, CMSS1, WWP2, TRIP6, CAV1, HTR1D, PDGFRB, AKT1, GNAI3, GNAI1, HTR1A,
Protein Size: 382

Molecular Weight: 43 kDa

Gene ID: 1901

NCBI Accession: NM_001400, NP_001391

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2