ATL1 antibody (C-Term)

Catalog No. ABIN2789990

The Rabbit Polyclonal anti-ATL1 antibody has been validated for WB. It is suitable to detect ATL1 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Pig and Rabbit.

Quick Overview for ATL1 antibody (C-Term) (ABIN2789990)

Target: ATL1 (Atlastin GTPase 1 (ATL1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATL1 Antibody

Binding Specificity: C-Term

Sequence: DQVAAALWDQ GSTNEALYKL YSAAATHRHL YHQAFPTPKS ESTEQSEKKK

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 100%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against SPG3A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human ATL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATL1

Target: ATL1 (Atlastin GTPase 1 (ATL1))

Alternative Name: SPG3A

Background: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: FSP1, GBP3, SPG3, HSN1D, SPG3A, AD-FSP, atlastin1
Protein Size: 475

Molecular Weight: 52 kDa

Gene ID: 51062

NCBI Accession: NM_001127713, NP_001121185

UniProt: Q8WXF7