ATL1 antibody (C-Term)

Catalog No. ABIN2789990

Product Details anti-ATL1 Antibody

Target: ATL1 (Atlastin GTPase 1 (ATL1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATL1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DQVAAALWDQ GSTNEALYKL YSAAATHRHL YHQAFPTPKS ESTEQSEKKK

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 100%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against SPG3A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human ATL1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATL1

Target: ATL1 (Atlastin GTPase 1 (ATL1))

Alternative Name: SPG3A (ATL1 Products)

Background: The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: FSP1, GBP3, SPG3, HSN1D, SPG3A, AD-FSP, atlastin1
Protein Size: 475

Molecular Weight: 52 kDa

Gene ID: 51062

NCBI Accession: NM_001127713, NP_001121185

UniProt: Q8WXF7