IPO7 antibody (C-Term)

Catalog No. ABIN2789995

This anti-IPO7 antibody is a Rabbit Polyclonal antibody detecting IPO7 in WB. Suitable for Human, Mouse, Cow, Rat, Dog, Horse, Guinea Pig, Rabbit, Pig and Zebrafish (Danio rerio).

Quick Overview for IPO7 antibody (C-Term) (ABIN2789995)

Target: IPO7 (Importin 7 (IPO7))

Reactivity: Human, Mouse, Cow, Rat, Dog, Horse, Guinea Pig, Rabbit, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IPO7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IPO7 Antibody

Binding Specificity: C-Term

Sequence: NVIQKMICEY SEEVTPIAVE MTQHLAMTFN QVIQTGPDEE GSDDKAVTAM

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against IPO7. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1038 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IPO7

Target: IPO7 (Importin 7 (IPO7))

Alternative Name: IPO7

Background: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions.
Alias Symbols: FLJ14581, Imp7, MGC138673, RANBP7
Protein Interaction Partner: SUMO2, SUMO3, STAU1, RNF2, rev, TNPO1, KARS, HSPA1L, HARS, APEH, PFDN5, NFRKB, ELAC2, CAND1, TRMT112, HSPA4L, RNASEH2A, FBXO6, EGFR, SOX2, METTL18, UBC, CFTR, CA9, IGBP1, RAN, CDK2, FBXO25, SIRT7, RNF146, MYC, AIRE, USP49, RPL23A, RPS7, RPL5, KPNB1, SRP19
Protein Size: 1038

Molecular Weight: 119 kDa

Gene ID: 10527

NCBI Accession: NM_006391, NP_006382

UniProt: O95373

Pathways: Protein targeting to Nucleus