L2HGDH antibody (Middle Region)

Catalog No. ABIN1544444

The Rabbit Polyclonal anti-L2HGDH antibody is suitable to detect L2HGDH in samples from Human, Mouse, Cow, Pig, Dog, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for L2HGDH antibody (Middle Region) (ABIN1544444)

Target: L2HGDH (L-2-Hydroxyglutarate Dehydrogenase (L2HGDH))

Reactivity: Human, Mouse, Cow, Pig, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L2HGDH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-L2HGDH Antibody

Binding Specificity: Middle Region

Sequence: GSVLTNFEVK GIEMAKESPS RSIDGMQYPI VIKNTKGEEI RCQYVVTCAG

Predicted Reactivity: Cow: 91%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 86%

Characteristics: This is a rabbit polyclonal antibody against L2HGDH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human L2HGDH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 463 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for L2HGDH

Target: L2HGDH (L-2-Hydroxyglutarate Dehydrogenase (L2HGDH))

Alternative Name: L2HGDH

Background: This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.
Alias Symbols: C14orf160, DURANIN, FLJ12618
Protein Interaction Partner: SUMO2, UBC,
Protein Size: 463

Molecular Weight: 45 kDa

Gene ID: 79944

NCBI Accession: NM_024884, NP_079160

UniProt: Q9H9P8