FKBP1A antibody (N-Term)

Catalog No. ABIN2790064

This anti-FKBP1A antibody is a Rabbit Polyclonal antibody detecting FKBP1A in WB. Suitable for Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Saccharomyces cerevisiae and Zebrafish (Danio rerio).

Quick Overview for FKBP1A antibody (N-Term) (ABIN2790064)

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP1A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FKBP1A Antibody

Binding Specificity: N-Term

Sequence: GQTCVVHYTG MLEDGKKFDS SRDRNKPFKF MLGKQEVIRG WEEGVAQMSV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against FKBP1A. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 108 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: FKBP1A

Background: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
Alias Symbols: FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PKCI2, PPIASE, FKBP-1A
Protein Interaction Partner: AHSP, SF3B4, MID1, MTOR, TGFB1, UBC, BAG3, ACVRL1, BARD1, ZPR1, APP, ELAVL1, ACVR1B, SMAD7, TRPC3, FKBP4, TGFB1I1, GLMN, PPP3R1, YY1, TGFBR1, FKBP1A, RYR3, RYR1, ITPR1, DHFR, PPP3CA, BMPR1A, RPTOR,
Protein Size: 108

Molecular Weight: 12 kDa

Gene ID: 2280

NCBI Accession: NM_000801, NP_000792

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process