NANS antibody (Middle Region)

Catalog No. ABIN2790122

The Rabbit Polyclonal anti-NANS antibody has been validated for WB. It is suitable to detect NANS in samples from Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse and Zebrafish (Danio rerio).

Quick Overview for NANS antibody (Middle Region) (ABIN2790122)

Target: NANS (N-Acetylneuraminic Acid Synthase (NANS))

Reactivity: Human, Rat, Mouse, Cow, Dog, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NANS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NANS Antibody

Binding Specificity: Middle Region

Sequence: GSGDTNNFPY LEKTAKKGRP MVISSGMQSM DTMKQVYQIV KPLNPNFCFL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against NANS. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 359 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NANS

Target: NANS (N-Acetylneuraminic Acid Synthase (NANS))

Alternative Name: NANS

Background: This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively, however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.
Alias Symbols: SAS
Protein Interaction Partner: SUMO2, UBC, NEDD8, ATG3, SMEK2, CNDP2, POLE3, DAK, NPEPPS, SLC9A3R1, RPLP2, MVD, PDIA3, GBP2, EIF4E, CKB, ASS1, BAG3, HSP90AB1, HSP90AA1, PCMT1, CRK, RAD23B, DDA1,
Protein Size: 359

Molecular Weight: 40 kDa

Gene ID: 54187

NCBI Accession: NM_018946, NP_061819

UniProt: Q9NR45