PTPN21 antibody (C-Term)

Catalog No. ABIN2790277

The Rabbit Polyclonal anti-PTPN21 antibody (ABIN2790277) specifically detects PTPN21 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) and Dog samples.

Quick Overview for PTPN21 antibody (C-Term) (ABIN2790277)

Target: PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN21 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PTPN21 Antibody

Binding Specificity: C-Term

Sequence: FWQMVWEQGI AIIAMVTAEE EGGREKSFRY WPRLGSRHNT VTYGRFKITT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PTPN21. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PTPN21

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1174 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PTPN21

Target: PTPN21 (Protein tyrosine Phosphatase, Non-Receptor Type 21 (PTPN21))

Alternative Name: PTPN21

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
Alias Symbols: PTPD1, PTPRL10
Protein Interaction Partner: KIF1C, AKAP1, TEC, BMX, SRC,
Protein Size: 1174

Molecular Weight: 133 kDa

Gene ID: 11099

NCBI Accession: NM_007039, NP_008970

UniProt: Q16825