Exportin 2 antibody (N-Term)

Catalog No. ABIN2792099

This anti-Exportin 2 antibody is a Rabbit Polyclonal antibody detecting Exportin 2 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Pig and Zebrafish (Danio rerio).

Quick Overview for Exportin 2 antibody (N-Term) (ABIN2792099)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Horse, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Exportin 2 Antibody

Binding Specificity: N-Term

Sequence: ELSDANLQTL TEYLKKTLDP DPAIRRPAEK FLESVEGNQN YPLLLLTLLE

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CSE1L. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CSE1L

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 971 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the protein may play a role both in apoptosis and in cell proliferation.Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CAS, CSE1, MGC117283, MGC130036, MGC130037, XPO2
Protein Interaction Partner: ERLIN2, HUWE1, UBC, FUS, SUMO2, STAU1, SUMO1, NEDD8, ASB16, RNF2, SUZ12, PDIA3, TBCB, CKB, GINS3, BCCIP, UBFD1, CNDP2, SCLY, CHORDC1, RRAGB, GDA, NPEPPS, SLC9A3R1, KYNU, TGM2, TCEA1, SMS, RPS6KA3, MVD, LDHA, FBXO6, YWHAQ, EGFR, UBD, PTMA, CLN3, HDAC6, MMS
Protein Size: 971

Molecular Weight: 110 kDa

Gene ID: 1434

NCBI Accession: NM_001316, NP_001307

UniProt: P55060

Pathways: Protein targeting to Nucleus