Caveolin 2 antibody (N-Term)

Catalog No. ABIN2792220

The Rabbit Polyclonal anti-Caveolin 2 antibody has been validated for WB and IHC. It is suitable to detect Caveolin 2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep and Horse. There is 1 publication available.

Quick Overview for Caveolin 2 antibody (N-Term) (ABIN2792220)

Target: Caveolin 2 (CAV2)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caveolin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Caveolin 2 Antibody

Binding Specificity: N-Term

Sequence: LVIPYNEKPE KPAKTQKTSL DEALQWRDSL DKLLQNNYGL ASFKSFLKSE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against CAV2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAV2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 162 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Caveolin 2 antibody (ABIN2792220)

Chi Sabins, Taylor, Fabian, Appleman, Maranchie, Stolz, Storkus: "DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 21, Issue 10, pp. 1958-68, (2013) (PubMed).

Target Details for Caveolin 2

Target: Caveolin 2 (CAV2)

Alternative Name: CAV2

Background: CAV2 is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.
Alias Symbols: CAV, MGC12294
Protein Interaction Partner: EGFR, PTGS1, CSNK2A1, CAV1, MALL, KCNMA1, UBC, DNAJA1, GOLGB1, NCK1, SRC, RASA1, FLOT2, DRD1, PLD2,
Protein Size: 162

Molecular Weight: 18 kDa

Gene ID: 858

NCBI Accession: NM_001233, NP_001224

UniProt: P51636

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development