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DOK2 antibody (C-Term)

This anti-DOK2 antibody is a Rabbit Polyclonal antibody detecting DOK2 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Pig and Horse.
Catalog No. ABIN2792223

Quick Overview for DOK2 antibody (C-Term) (ABIN2792223)

Target

See all DOK2 Antibodies
DOK2

Reactivity

  • 104
  • 68
  • 17
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human, Mouse, Rat, Cow, Dog, Pig, Horse

Host

  • 115
  • 4
Rabbit

Clonality

  • 115
  • 4
Polyclonal

Conjugate

  • 41
  • 7
  • 7
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This DOK2 antibody is un-conjugated

Application

  • 99
  • 52
  • 52
  • 39
  • 26
  • 18
  • 13
  • 12
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Binding Specificity

    • 26
    • 22
    • 15
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Sequence

    QEPRGEAWRR QATRDRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG

    Predicted Reactivity

    Cow: 100%, Dog: 90%, Horse: 90%, Human: 100%, Mouse: 90%, Pig: 100%, Rat: 90%

    Characteristics

    This is a rabbit polyclonal antibody against DOK2. It was validated on Western Blot using a cell lysate as a positive control.

    Purification

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the C terminal region of human DOK2
  • Application Notes

    Optimal working dilutions should be determined experimentally by the investigator.

    Comment

    Antigen size: 412 AA

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freeze-thaw cycles.

    Storage

    -20 °C

    Storage Comment

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    DOK2

    Alternative Name

    DOK2

    Background

    DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
    Alias Symbols: p56DOK, p56dok-2
    Protein Interaction Partner: UBC, RASA1, ABL1, POT1, EGFR, KIAA1279, INPP5D, NCK1, TEK, SRC, LYN, RET, LCK, IL4R, HCK, HSPA4L, ASF1B, DNAJB11, RAB10, SSSCA1, CFLAR, SPOP, SHC1, PSMD10, DOK1,
    Protein Size: 412

    Molecular Weight

    45 kDa

    Gene ID

    9046

    NCBI Accession

    NM_003974, NP_003965

    UniProt

    O60496
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