RNASEL antibody (C-Term)

Catalog No. ABIN184206

The Rabbit Polyclonal anti-RNASEL antibody (ABIN184206) specifically detects RNASEL in WB. The antibody is reactive with Human, Pig, Cow, Dog and Horse samples.

Quick Overview for RNASEL antibody (C-Term) (ABIN184206)

Target: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Reactivity: Human, Pig, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEL antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RNASEL Antibody

Binding Specificity: C-Term

Sequence: MKLKIGDPSL YFQKTFPDLV IYVYTKLQNT EYRKHFPQTH SPNKPQCDGA

Predicted Reactivity: Cow: 78%, Dog: 92%, Horse: 100%, Human: 100%, Pig: 92%

Characteristics: This is a rabbit polyclonal antibody against RNASEL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RNASEL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 741 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RNASEL

Target: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Alternative Name: RNASEL

Background: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
Alias Symbols: RNS4, PRCA1
Protein Interaction Partner: TCF12, UBC, ABCE1, AR, GSPT1,
Protein Size: 741

Molecular Weight: 84 kDa

Gene ID: 6041

NCBI Accession: NM_021133, NP_066956

UniProt: Q05823

Pathways: Hepatitis C