PDCD4 antibody (N-Term)

Catalog No. ABIN2792230

The Rabbit Polyclonal anti-PDCD4 antibody has been validated for WB. It is suitable to detect PDCD4 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig and Goat. There are 2+ publications available.

Quick Overview for PDCD4 antibody (N-Term) (ABIN2792230)

Target: PDCD4 (Programmed Cell Death 4 (PDCD4))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDCD4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDCD4 Antibody

Binding Specificity: N-Term

Sequence: MTKYPDNLSD SLFSGDEENA GTEEIKNEIN GNWISASSIN EARINAKAKR

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PDCD4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PDCD4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 458 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-PDCD4 antibody (ABIN2792230)

Pan, Luo, Chegini: "microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells." in: Molecular human reproduction, Vol. 16, Issue 3, pp. 215-27, (2010) (PubMed).

Folini, Gandellini, Longoni, Profumo, Callari, Pennati, Colecchia, Supino, Veneroni, Salvioni, Valdagni, Daidone, Zaffaroni: "miR-21: an oncomir on strike in prostate cancer." in: Molecular cancer, Vol. 9, pp. 12, (2010) (PubMed).

Target Details for PDCD4

Target: PDCD4 (Programmed Cell Death 4 (PDCD4))

Alternative Name: PDCD4

Background: PDCD4 is a protein localized to the nucleus in proliferating cells. Expression of its gene is modulated by cytokines in natural killer and T cells. PDCD4 is thought to play a role in apoptosis but the specific role has not yet been determined.This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.
Alias Symbols: H731, MGC33046, MGC33047
Protein Interaction Partner: EIF4A2, FBXW11, EIF4A3, PAIP1, ARPC1B, UFD1L, TPD52, BTF3, AAMP, IGSF8, CD81, DAXX, UBC, CSNK2A1, VCP, NR1H2, PSEN2, PSEN1, NAP1L1, APOE, BTRC, RPS6KA1, EIF4A1, ELAVL1, SUMO2, EMD, PDCD4, EIF4G1, RPL5, RPLP1, RPS13,
Protein Size: 458

Molecular Weight: 50 kDa

Gene ID: 27250

NCBI Accession: NM_145341, NP_663314

UniProt: Q53EL6